ORAL CRYOTHERAPY PREVENTS ORAL MUCOSITIS IN CANCER PATIENTS UNDERGOING CHEMOTHERAPY AT ODC OF YOGYAKARTA PRIVATE HOSPITAL

Authors

  • Neni Puspita Guningsih Program Studi Keperawatan, Sekolah Tinggi Ilmu Kesehatan Panti Rapih Yogyakarta, Indonesia
  • Fransisca Anjar Rina Setyani Program Studi Keperawatan, Sekolah Tinggi Ilmu Kesehatan Panti Rapih Yogyakarta, Indonesia
  • Elisabeth Herlina Suminarhati Program Studi Keperawatan, Sekolah Tinggi Ilmu Kesehatan Panti Rapih Yogyakarta, Indonesia

DOI:

https://doi.org/10.36916/jkm.v11i1.389

Keywords:

Cryotherapy, Mucositis, Chemotherapy

Abstract

Background: Cancer patients receiving chemotherapy agents often experience the side effect of oral mucositis. One complementary therapy to prevent oral mucositis is oral cryotherapy, as it causes vasoconstriction in the oral mucosa area, thereby reducing the amount of blood containing chemotherapy drugs reaching the oral mucosa area.

Purpose: The objective of this study was to determine the effect of oral cryotherapy on reducing the severity of oral mucositis in cancer patients undergoing chemotherapy in the ODC chemotherapy room at Private Hospital in Yogyakarta

Methods: This study used a quasi-experimental research design. The study population consisted of 38 cancer patients undergoing chemotherapy with doxorubicin, cyclophosphamide, and 5-fluorouracil. A sample of 32 respondents was selected using systematic sampling techniques and divided into two groups of 18 people each in the control and intervention groups. In the intervention group, respondents were instructed to brush their teeth, rinse their mouths, and then suck on ice chips over the entire surface of the oral mucosa for 20 minutes immediately after the chemotherapy drugs were administered and for 7 consecutive days thereafter, while the control group received no intervention. The author observed oral mucositis using the Oral Assessment Guide (OAG) on day 1 and day 7

Result: Data analysis using the Mann Whitney test showed that oral cryotherapy had an effect on the degree of oral mucositis in cancer patients undergoing chemotherapy in the ODC chemotherapy room at Private Hospital (P value = 0.00)

Implication: Nurses can administer oral cryotherapy to prevent oral mucositis in cancer patients undergoing chemotherapy in the ODC Chemotherapy Room at Private Hospital in Yogyakarta

Keywords: Cryotherapy; Mucositis; Chemotherapy

References

Adel, M., El-Tohamy, M., & Abusaad, F. E. (n.d.). Effectiveness of Flavored Oral Cryotherapy On The Prevention And Management Of Stomatitis Induced By Chemotherapy. In Mansoura Nursing Journal (MNJ), 8(1), 133-144

Ajani, A. T., Malini, H., & Fatmadona, R. (2019). Hubungan Cryotherapy terhadap Mukositis Oral pada Pasien Kanker Payudara dengan Kemoterapi di Ruangan Kemoterapi Rumah Sakit M. Djamil Padang. In Jurnal Kesehatan Andalas. 8(4). https://doi.org/10.25077/jka.v8i4.1093

Al-Rudayni, A. H. M., Gopinath, D., Maharajan, M. K., Veettil, S. K., & Menon, R. K. (2021). Efficacy of oral cryotherapy in the prevention of oral mucositis associated with cancer chemotherapy: Systematic review with meta-analysis and trial sequential analysis. In Current Oncology, 28(4), 2852–2867. https://doi.org/10.3390/curroncol28040250

American Cancer Society. (2023). Breast Cancer. https://www.cancer.org/cancer/types/breast-cancer.html

Ardhiansyah, A. O. (2021). Mengatasi Efek samping Kemoterapi. Airlangga University Press.

Beech, N., Robinson, S., Porceddu, S., & Batstone, M. (2014). Dental management of patients irradiated for head and neck cancer. Australian Dental Journal, 59(1), 20–28. https://doi.org/10.1111/adj.12134

Cidon, E. U. (2018). Chemotherapy induced oral mucositis: Prevention is possible. Chinese Clinical Oncology, 7(1). https://doi.org/10.21037/cco.2017.10.01

Eghbali, A., Taherkhanchi, B., Bagheri, B., & Sedeh, B. S. (2016). Effect of Chewing Gum on Oral Mucositis in Children Undergoing Chemotherapy: a Randomized Controlled Study. Iranian Journal of Pediatric Hematology Oncology, 6(1), 9–14. https://pmc.ncbi.nlm.nih.gov/articles/PMC4867166/

Erika, K. A., Mulhaeriah, M., Miskad, U. A., Zuraida, E., Sangkala, M. S., Magfirah, I., & Achmad, H. (2025). Cryotherapy on exfoliative cytological changes for oral mucositis in cancer patients undergoing chemotherapy: A randomized control trial. Narra J, 5(2). https://doi.org/10.52225/narra.v5i2.1644

Hendrawati, S., Nurhidayah, I., Mediani, H. S., & Mardhiyah, A. (2020). Incident of Mucositis and The Factors that Influence it on Children with Cancer Who Received Chemotherapy. Jurnal Keperawatan, 10(2), 139–150. https://doi.org/10.22219/jk.v10i2.5498

Ladesvita, F., Waluyo, A., Yona, S., Keperawatan, J., Ilmu, F., Upn, K., Jakarta, V., Keperawatan, F. I., & Indonesia, U. (2020). PENERAPAN ORAL ASSESSMENT GUIDE (OAG) PADA PASIEN KANKER DENGAN KEMOTERAPI. In Jurnal Keperawatan Widya Gantari Indonesia, 4(2).

López-González, Á., García-Quintanilla, M., Guerrero-Agenjo, C. M., Tendero, J. L., Guisado-Requena, I. M., & Rabanales-Sotos, J. (2021). Efficacy of cryotherapy in the prevention of oral mucositis in adult patients with chemotherapy. In International Journal of Environmental Research and Public Health. 18(3), 1–15. MDPI AG. https://doi.org/10.3390/ijerph18030994

Kementerian Kesehatan RI. (2024). Profil Kesehatan Indonesia 2024.

Muhammad T.Amjad, Anusha Chidharla, & Anup Kasi. (2023). Kemoterapi Kanker. National Library of Medicine: StatPearls Publishing.

Nawi, R. I. M., Chui, P. L., Wan Ishak, W. Z., & Hsien Chan, C. M. (2018). Oral cryotherapy: Prevention of oral mucositis and pain among patients with colorectal cancer undergoing chemotherapy. Clinical Journal of Oncology Nursing, 22(5), 555–560. https://doi.org/10.1188/18.CJON.555-560

Sianturi, E., & Irawati, D. (2019). The The Effectiveness Of Oral Cryotherapy To Reduce Oral Mucositis Among Cancer Patients Undergoing Chemotherapy: A Literature Review. International Journal of Nursing and Health Services (IJNHS), 2(2), 102–109. https://doi.org/10.35654/ijnhs.v2i2.108

Silaban, N. Y., Nasution, S. S., & Siregar, C. T. (2020). Influences of oral cryotherapy on mucositis prevention in cancer patients with chemotherapy. Jurnal Kedokteran Dan Kesehatan Indonesia, 11(2), 165–171. https://doi.org/10.20885/jkki.vol11.iss2.art9

Downloads

Published

2026-04-24

Citation Check