BLOOD GLUCOSE LEVELS IN PREGNANT WOMEN AT 24–28 WEEKS OF GESTATION DURING THE SECOND TRIMESTER FOR THE DETECTION OF GESTATIONAL DIABETES MELLITUS RISK

Authors

  • Syahilla Putri Fairuza Prodi D3 Keperawatan Blitar, Poltekkes Kemenkes Malang, Indonesia
  • Dewi Rachmawati Prodi D3 Keperawatan Blitar, Poltekkes Kemenkes Malang, Indonesia
  • Sri Mugianti Prodi D3 Keperawatan Blitar, Poltekkes Kemenkes Malang, Indonesia

DOI:

https://doi.org/10.36916/jkm.v11i1.403

Keywords:

Blood Glucose, Pregnant Women, Gestation Age 24-28 Weeks

Abstract

Background: Pregnant women in the second trimester experience physical and hormonal changes, as well as increased insulin resistance, which may lead to elevated blood glucose levels. If not detected early, these conditions may increase the risk of developing gestational diabetes mellitus.

Objective: To determine the blood glucose levels of pregnant women in the second trimester at 24–28 weeks of gestation in order to detect the risk of gestational diabetes mellitus.

Methods: This study employed a quantitative descriptive design. The population consisted of 37 pregnant women, with a total of 30 respondents selected through purposive sampling. The inclusion criteria were pregnant women in the second trimester with a gestational age of 24–28 weeks. Data collection was conducted from March 6 to March 31, 2024. The research instruments included a structured interview questionnaire consisting of factors influencing gestational diabetes mellitus and an observation sheet.

Results: The results showed that 10% of pregnant women were classified as having prediabetes, while 90% had random blood glucose levels within the normal range. Blood glucose levels were influenced by factors such as age, history of diabetes mellitus, overweight status, history of polycystic ovary syndrome (PCOS), and consumption of sweet foods.

Implications: Early detection is necessary to identify gestational diabetes mellitus beginning in the early trimester of pregnancy, along with regular antenatal care (ANC) examinations

Keywords: Blood Glucose; Pregnant Women; Gestation Age 24-28 Weeks

References

Alfadhli, E. M. (2015). Gestational diabetes mellitus. Saudi Medical Journal, 36(4), 399–406. https://doi.org/10.15537/smj.2015.4.10307

Amiri, F. N., Faramarzi, M., Bakhtiari, A., & Omidvar, S. (2021). Risk Factors for Gestational Diabetes Mellitus: A Case-Control Study. American Journal of Lifestyle Medicine, 15(2), 184–190. https://doi.org/10.1177/1559827618791980

Anissa, K., Rumahorbo, H., & Wahyuni, S. (2023). Development of Instruments Test to Detect Diabetes Mellitus in Pregnancy. Jurnal Kebidanan, 12(1), 27. https://doi.org/10.26714/jk.12.1.2023.27-36

Baddock, S., Petersons, C., & Nolan, C. J. (2025). Gestational diabetes: update on screening, diagnosis and maternal management. Australian Prescriber, 48(5), 167–172. https://doi.org/10.18773/austprescr.2025.045

Bastian, B., Smithers, L. G., Pape, A., Davis, W., Fu, K., & Francois, M. (2024). Early screening and diagnosis of gestational diabetes mellitus (GDM) and its impact on perinatal outcomes. Diabetes Research and Clinical Practice, 217, 111890. https://doi.org/https://doi.org/10.1016/j.diabres.2024.111890

Benhalima, K., Damm, P., Van Assche, A., Mathieu, C., Devlieger, R., Mahmood, T., & Dunne, F. (2016). Screening for gestational diabetes in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board & College of Obstetrics and Gynaecology (EBCOG). European Journal of Obstetrics & Gynecology and Reproductive Biology, 201, 192–196. https://doi.org/https://doi.org/10.1016/j.ejogrb.2016.04.002

Canday, M. (2024). Identifying gestational diabetes mellitus and assessing risk factors in affected women: a comprehensive study. European Review for Medical and Pharmacological Sciences, 28(2), 734–746. https://doi.org/10.26355/eurrev_202401_35073

Caputo, M., Bullara, V., Mele, C., Samà, M. T., Zavattaro, M., Ferrero, A., Daffara, T., Leone, I., Giachetti, G., Antoniotti, V., Longo, D., De Pedrini, A., Marzullo, P., Remorgida, V., Prodam, F., & Aimaretti, G. (2021). Gestational Diabetes Mellitus: Clinical Characteristics and Perinatal Outcomes in a Multiethnic Population of North Italy. International Journal of Endocrinology, 2021. https://doi.org/10.1155/2021/9474805

Corcoran, S. M., Achamallah, N., Loughlin, J. O., Stafford, P., Dicker, P., Malone, F. D., & Breathnach, F. (2018). First trimester serum biomarkers to predict gestational diabetes in a high-risk cohort: Striving for clinically useful thresholds. European Journal of Obstetrics & Gynecology and Reproductive Biology, 222, 7–12. https://doi.org/https://doi.org/10.1016/j.ejogrb.2017.12.051

Cuschieri, S., & Savona-Ventura, C. (2016). Gestational diabetes mellitus: to screen or not to screen; that is the question! Obstetrics, Gynaecology & Reproductive Medicine, 26(8), 247–248. https://doi.org/https://doi.org/10.1016/j.ogrm.2016.05.005

Feig, Denice; Berger, Howard; Donovan, Lois; Godbout, Ariane; Kader, Tina; Keely, Erin; Sanghera, R. (2019). Diabetes Canada 2018 Clinical Practice Guidelines. Canadian Journal of Diabetes, 65(1), 255–282.

Grewal, E., Kansara, S., Kachhawa, G., Ammini, A. C., Kriplani, A., Aggarwal, N., Gupta, N., & Khadgawat, R. (2012). Prediction of gestational diabetes mellitus at 24 to 28 weeks of gestation by using first-trimester insulin sensitivity indices in Asian Indian subjects. Metabolism, 61(5), 715–720. https://doi.org/https://doi.org/10.1016/j.metabol.2011.10.009

Harahap, N. H., Harahap, I., Siregar, R., Nasution, N. A., Almadany, U. H., & Dongoran, R. F. (2025). Gambaran Pengetahuan Ibu Hamil Tentang Diabetes Gestasional Di Puskesmas Sipiongot Tahun 2024. Jurnal Kesehatan Ilmiah Indonesia (Indonesian Health Scientific Journal), 10(1). https://doi.org/10.51933/health.v10i1.1661

Jasmine, B., Stanley, J. L., & Baker, P. N. (2025). Patofisiologi Diabetes Melitus Gestasional. Jurnal Ilmiah, 3(1), 68–73.

Kunarathnam V, Vadakekut ES, M. H. (2026). Gestational Diabetes. StatPearls [Internet] Publishing. rom: https://www.ncbi.nlm.nih.gov/books

Mazeda, M. L., Silva, B., Cidade-Rodrigues, C., Moreira, F., Benido-Silva, V., Gomes, V., Chaves, C., Pereira, C. A., Machado, C., Figueiredo, O., Melo, A., Martinho, M., Ferreira, A., Morgado, A., Almeida, M. do C., Saavedra, A., Almeida, M., & Cunha, F. M. (2025). Association Between Hypoglycaemia at the 24–28th-Week OGTT and Obstetric and Neonatal Outcomes in Women with Gestational Diabetes. Diabetology, 6(10), 1–12. https://doi.org/10.3390/diabetology6100106

Mittal, R., Prasad, K., Lemos, J. R. N., Arevalo, G., & Hirani, K. (2025). Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management. International Journal of Molecular Sciences, 26(5), 1–42. https://doi.org/10.3390/ijms26052320

Moon, J. H., & Jang, H. C. (2022). Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications. Diabetes and Metabolism Journal, 46(1), 3–14. https://doi.org/10.4093/DMJ.2021.0335

Nakshine, V. S., & Jogdand, S. D. (2023). A Comprehensive Review of Gestational Diabetes Mellitus: Impacts on Maternal Health, Fetal Development, Childhood Outcomes, and Long-Term Treatment Strategies. Cureus, 15(10). https://doi.org/10.7759/cureus.47500

Nigam, A., Varun, N., Sharma, S., Munjal, Y. P., & Prakash, A. (2020). Glycaemic profile in the second and third trimesters of normal pregnancy compared to non-pregnant adult females. Obstetric Medicine, 13(1), 30–36. https://doi.org/10.1177/1753495X18807549

Nurbita Fajarini, Nurbita, Mufdlillah, Satriyandari, Y. (2021). Hambatan Pelaksanaan Skrining Gestational Diabetes Mellitus (GDM) Di Kota Yogyakarta. 48(2), 39–62. www.ine.es

Phaloprakarn, C., & Tangjitgamol, S. (2022). Glucose levels during gestational diabetes pregnancy and the risk of developing postpartum diabetes or prediabetes. BMC Pregnancy and Childbirth, 22(1), 1–8. https://doi.org/10.1186/s12884-021-04352-w

Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018). The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences, 19(11), 1–21. https://doi.org/10.3390/ijms19113342

Prabhu J, K., Deepthi Kondamuri, S., Samal, S., & Sen, M. (2021). Knowledge of gestational diabetes mellitus among pregnant women in a semiurban hospital - A cross -sectional study. Clinical Epidemiology and Global Health, 12(July), 100854. https://doi.org/10.1016/j.cegh.2021.100854

Rahmawati, F., Natosba, J., & Jaji. (2016). Skrining Diabetes Mellitus Gestasional dan Faktor Risiko yang Mempengaruhinya. Jurnal Keperawatan Sriwijaya, 3(2), 2355 5459.

Rodrigo, N., & Glastras, S. J. (2020). Pathophysiology Underpinning Gestational Diabetes Mellitus and the Role of Biomarkers for its Prediction. EMJ Diabetes, (May). https://doi.org/10.33590/emj/19-00150

Sweeting, A., Hannah, W., Backman, H., Catalano, P., Feghali, M., Herman, W. H., Hivert, M.-F., Immanuel, J., Meek, C., Oppermann, M. L., Nolan, C. J., Ram, U., Schmidt, M. I., Simmons, D., Chivese, T., & Benhalima, K. (2024). Epidemiology and management of gestational diabetes. Lancet (London, England), 404(10448), 175–192. https://doi.org/10.1016/S0140-6736(24)00825-0

Ying, Q., Xu, Y., Zhang, Z., Cai, L., Zhao, Y., & Jin, L. (2024). Gestational diabetes mellitus and risk of long-term all-cause and cardiac mortality: a prospective cohort study. Cardiovascular Diabetology, 23(1), 47. https://doi.org/10.1186/s12933-024-02131-3

Downloads

Published

2026-05-22

Citation Check